The impact of clonal hematopoiesis on outcomes in patients with aplastic anemia

Over the years, not only have T-cell mediated immune mechanisms of aplastic anemia (AA) involved in AA development started to become better understood, but there is now also a understanding roles played by somatic mutations, cytogenetic abnormalities and defective telomerase functions other genetically-related factors. Somatic gene mutations suggestive clonal hematopoiesis are detected approximately one third patients with AA. Recent studies suggested that some these may predict response immunosuppressive therapy, whereas others indicate poorer outcomes higher risks evolution myelodysplastic syndrome or acute myeloid leukemia, therefore results be obtained based on allogeneic stem cell transplantation. Furthermore, recent advances molecular techniques useful differentiating from hypocellular hematopoiesises indeterminate potential. All summarized this review which includes further insights into treatment personalization pathogenesis